A Handbook for Dna-Encoded Chemistry

This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: * Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry * Helps chemists generate and screen novel chemical libraries of large size and quality * Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry - synthetic and analytical chemistry, molecular biology, informatics, and biochemistry * Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery * Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods