Adme and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins
Autor: | Theil, Frank-Peter Zhou, Honghui |
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EAN: | 9781118898642 |
Sachgruppe: | Chemie |
Sprache: | Englisch |
Seitenzahl: | 480 |
Produktart: | Gebunden |
Veröffentlichungsdatum: | 23.11.2015 |
Untertitel: | Applications in Drug Discovery and Development |
Schlagworte: | Medical / Nursing |
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With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. * Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs * Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective * Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines * Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan * Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain