Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of ¿-Aryl Ketones
| Autor: | Doran, Robert |
|---|---|
| EAN: | 9783319205434 |
| Sachgruppe: | Chemie |
| Sprache: | Englisch |
| Seitenzahl: | 224 |
| Produktart: | Gebunden |
| Veröffentlichungsdatum: | 09.07.2015 |
| Schlagworte: | Chemie / Medizin Katalyse - Katalysator - Biokatalyse - Biokatalysator |
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This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.
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