Design & Evaluation of Controlled Release Matrix Tablets of Prazosin
| Autor: | Atul Tiwari, Pankaj Chasta Kothari, Rajan Sharma, Gaurav Kumar |
|---|---|
| EAN: | 9786138387824 |
| Sachgruppe: | Medizin |
| Sprache: | Englisch |
| Seitenzahl: | 76 |
| Produktart: | Kartoniert / Broschiert |
| Veröffentlichungsdatum: | 03.04.2018 |
| Untertitel: | Modern Management of Hypertension |
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In the present study, we have prepared matrix tablet formulations using Prazocin as a model drug and Ethyl Cellulose, Two grades of Hydroxy Propyl Methyl Cellulose- HPMC-K4M & HPMC-K100M as polymers in different ratios. The developed matrix tablets were evaluated for different physical-chemical evaluations like drug content, hardness, friability, swelling index etc. All the formulations had shown the results within prescribed limits. The In vitro drug release study indicates that formulation PCF-7 containing EC, HPMC K100M in 1:2 ratio shown good release pattern for 14 hours compares to other formulations. The short-term stability study proved no change in the formulation of ageing and it indicates good stability.
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