Distribution and Phenotype of Proliferating Cells in the Forebrain of Adult Macaque Monkeys after Transient Global Cerebral Ischemia
| Autor: | A.B. Tonchev, T. Yamashima, G.N. Chaldakov |
|---|---|
| EAN: | 9783540396178 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 11.03.2007 |
| Kategorie: | |
| Schlagworte: | Cortex Nervous System adult primate brain progenitor cell cell proliferation forebrain gliogenesis hippocampus neocortex neurogenesis olfactory bilb phenotype striatum subventricular zone |
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The authors' results show that ischemia differentially activates endogenous neural precursors residing in diverse locations of the adult primate central nervous system. A limited endogenous potential for postischemic neuronal repair exists in neocortex and striatum, but not in the hippocampus proper of the adult macaque monkey brain. The presence of putative parenchymal progenitors and of sustained progenitors in germinative centers opens novel possibilities for precursor cell recruitment.