Drug-DNA Interactions

ACCESSIBLE, COMPREHENSIVE INFORMATION ON DRUG-DNA INTERACTIONS. This informative guide is a thorough source of information on the structural basis of drug-DNA interactions and their underlying empirical evidence. It helps readers understand the underlying mechanisms of the interactions, thus expediting research and aiding in the more efficient design of new and more effective drugs with lesser side effects. With a wealth of information gleaned from diverse studies and combined in a logical, practical format, Drug-DNA Interactions: Structures and Spectra: Describes what types of structural information can be obtained using particular techniques Classified structural and spectroscopic studies of drug-DNA adducts first by bonding types and then by the structure type of the drug Covers intercalating drugs, groove-binding drugs, covalent-bonding drugs, strand-breaking drugs, and metal-containing drugs Focuses on structural and bonding information obtained by using physico-chemical methods (such as X-ray crystallography, NMR spectroscopy, and molecular modeling), and optical spectroscopy (such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), and infrared (IR) and Raman spectroscopy) This is a hands-on reference for professionals in pharmaceutical industries and academia, pharmacologists, organic chemists, biochemists, and bioanalytical chemists. It also helps students in chemistry, biochemistry, and pharmacology understand the complex drug-DNA interactions that could pave the way for tomorrow's breakthrough therapies.