| EAN: | 9781493990795 |
|---|---|
| Auflage: | 001 |
| Sachgruppe: | Medizin |
| Sprache: | Englisch |
| Seitenzahl: | 204 |
| Produktart: | Gebunden |
| Herausgeber: | Ben-Yosef, Dalit Mayshar, Yoav |
| Veröffentlichungsdatum: | 22.03.2019 |
| Untertitel: | Methods and Protocols |
| Schlagworte: | AtaxiaSyndrome; FXTAS; Drosophila; C.elegans; CRISPR Biologie / Molekularbiologie Forschung (medizinisch, psychologisch) Genetik, Medizin Genetik / Humangenetik Heilkunde Humangenetik Humanmedizin Medizin Molekularbiologie Neurologie Neurologie / Neurophysiologie Neurologie und klinische Neurophysiologie Neurophysiologie Physiologie / Neurophysiologie |
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This volume discusses the latest technologies used to study all aspects of Fragile-X Syndrome (FXS). The chapters in this book cover topics such as monitoring for epigenetic modifications at the FMR1 locus; modeling FXS with human pluripotent stem cells, mouse neural progenitors; mouse versus human-based models for FXS pre-clinical research; and Fragile-X associated with Tremor/Ataxia Syndrome (FXTAS). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Fragile-X Syndrome: Methods and Protocols is a valuable tool to help scientists working towards one day developing a therapeutic solution to improve the symptoms of FXS. Chapter "Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.