Medicinal Chemistry Approaches to Personalized Medicine
| Autor: | Karen Lackey, Bruce Roth, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers |
|---|---|
| EAN: | 9783527677283 |
| eBook Format: | ePUB/PDF |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 22.11.2013 |
| Kategorie: | |
| Schlagworte: | Bruce D. Roth Crizotinib DNA damage repair pathways and synthetic letha Gerd Folkers Hugo Kubinyi Karen Lackey Medicinal Chemistry Approaches to Personalized Medicine Pharmaceutical & Medicinal Chemistry Raimund Mannhold Vismodegib Zelboraf |
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Edited by two famous medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues.
Numerous case studies from the first generation of 'personalized dugs' are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered.
With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come.
Karen Lackey joined Hoffmann-La Roche Pharma Research and Early Development in 2010 as Vice President and Head of Medicinal Chemistry at the Nutley, NJ (USA) site, where she is responsible for oncology, inflammation, virology and new technologies. In her previous role, she was the Vice President of Chemistry, Molecular Discovery Research for GlaxoSmithKline. During her 22-year career at GSK, Karen held a variety of positions and contributed to small molecule research, new technology, and systems-based research. Most importantly, she played an active role in the discovery of the dual erbB2/EGFR tyrosine kinase inhibitor, lapatinib, currently marketed as Tykerb.
Bruce Roth is currently Vice President of Discovery Chemistry in Genentech Research and Early Development at South San Francisco (USA). Prior to joining Genentech in 2007, he was Vice President of Discovery Chemistry at the Pfizer Global Research and Development Ann Arbor site where he was also an adjunct Associate Professor in the Medicinal Chemistry Department in the University of Michigan College of Pharmacy. Bruce began his career as a medicinal chemist at Warner-Lambert/ Parke-Davis in 1982 and is best known as the inventor of Lipitor (atorvastatin calcium), for which he has received numerous awards, including the 1999 'Inventor of the Year Award' from the New York Intellectual Property Law Association, the 2003 American Chemical Society Award for Creative Invention and the 2003 Gustavus J. Esselen Award. In 2008 he was named one of the American Chemical Society's Heroes in Chemistry.
Numerous case studies from the first generation of 'personalized dugs' are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered.
With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come.
Karen Lackey joined Hoffmann-La Roche Pharma Research and Early Development in 2010 as Vice President and Head of Medicinal Chemistry at the Nutley, NJ (USA) site, where she is responsible for oncology, inflammation, virology and new technologies. In her previous role, she was the Vice President of Chemistry, Molecular Discovery Research for GlaxoSmithKline. During her 22-year career at GSK, Karen held a variety of positions and contributed to small molecule research, new technology, and systems-based research. Most importantly, she played an active role in the discovery of the dual erbB2/EGFR tyrosine kinase inhibitor, lapatinib, currently marketed as Tykerb.
Bruce Roth is currently Vice President of Discovery Chemistry in Genentech Research and Early Development at South San Francisco (USA). Prior to joining Genentech in 2007, he was Vice President of Discovery Chemistry at the Pfizer Global Research and Development Ann Arbor site where he was also an adjunct Associate Professor in the Medicinal Chemistry Department in the University of Michigan College of Pharmacy. Bruce began his career as a medicinal chemist at Warner-Lambert/ Parke-Davis in 1982 and is best known as the inventor of Lipitor (atorvastatin calcium), for which he has received numerous awards, including the 1999 'Inventor of the Year Award' from the New York Intellectual Property Law Association, the 2003 American Chemical Society Award for Creative Invention and the 2003 Gustavus J. Esselen Award. In 2008 he was named one of the American Chemical Society's Heroes in Chemistry.