Mesenchymal Stem Cells

Mesenchymal Stem Cells: Biological Concepts, Current Advances, Opportunities and Challenges systematically summarizes and discusses the basic concepts and latest updates of mesenchymal stem cells (MSCs) in the past 60 years, as well as the latest progress of clinical translational research and regulatory policy at home and abroad, which will be of great practical significance for promoting and guiding the future development of stem cell production and regenerative medicine. - Systematically introduces the latest updates on Mesenchymal stem cells (MSCs), helping readers have a systematic understanding of MSCs - Summarizes knowledge on MSC-based cytotherapy in clinical practice to benefit clinicians and help them design MSC-relevant clinical trials - Introduces newly developed concepts of MSC-based tissue engineering

Dr. Leisheng Zhang's interests mainly focus on the biological function and molecular mechanism of mesenchymal stem/stromal cells (MSCs), including early development from human pluripotent stem cells (hPSCs), cellular phenotype and genomic analysis, and applied transformation research. He and his colleagues have identified a number of master regulators (TWIST1, MSX2, PRAME) during early MSC development. Simultaneously, his group has been working on immune cells, and, in particular, natural killer (NK) cells, on the basis of single cell sequencing and Raman spectroscopy. Representative studies of his group are available in journals such as Cell Research (2015), Journal of Hematology & Oncology (2017), Stem Cell Reports (2018), Stem Cell Research & Therapy (2018, 2019a, 2019b, 2020, 2021), Stem Cell Reviews and Reports (2020), Cell & Bioscience (2020), Cell Proliferation (2021), Stem Cells International (2020, 2021), and the American Journal of Cancer Research (2021).