| EAN: | 9789400751279 |
|---|---|
| Sachgruppe: | Biologie |
| Sprache: | Englisch |
| Seitenzahl: | 136 |
| Produktart: | Gebunden |
| Herausgeber: | Barron, Niall |
| Veröffentlichungsdatum: | 16.11.2012 |
| Schlagworte: | Arznei - Arzneimittel Gentechnologie - Gentechnik Medikament Pharmaka Tablette Technologie / Gentechnologie Tier Zoologie / Tier |
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Focused manuscript on the potential use/role of miRNAs in bioprocessing, specifically the production of complex proteins in mammalian cells. With that in mind I propose a draft list of topics/chapters along the following lines: Intro on CHO/bioprocessing/engineering challenges to set scene, Genomic organization, biogenesis and mode of action, Identifying miRNA targets: Computational prediction, transcriptomics, proteomices, UTR analysis, etc., miRNA expression in Chinese Hamster Ovary cells, miRNAs as engineering targets: pathway manipulation to impact bioprocess phenotypes, miRNAs as biomarkers, Detection methods: Northern, PCR, hybridization arrays, Next Gen Seq, Manipulation of expression in cultured cells: Transient/stable disregulation, Knockout.
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