Modern Methods in Stereoselective Aldol Reactions

This sequel to the highly successful and much appreciated 'Modern Aldol Reactions' continues to provide a systematic overview of methodologies for installing a required configuration during an aldol addition step, but shifts the focus so as to cover the latest developments.
As such, it presents a set of brand new tools, including vinylogous Mukaiyama-aldol reactions, substrate-controlled aldol reactions and asymmetric induction in aldol additions. Furthermore, novel developments in existing stereoselective aldol additions are described, such as the deployment of supersilyl groups or organocatalyzed aldol additions. Throughout, all of these methodologies are presented in the context of their deployment in total synthesis of natural products.


Born in 1950, Rainer Mahrwald studied chemistry at MLU Halle and subsequently joined the 'Manfred von Ardenne' Research Institute in Dresden, where he led the synthetics group. He gained his doctorate under G. Wagner in Leipzig in 1979, and went on to the Institute of Organic Chemistry at the Academy of Science in Berlin, where he remained until 1990. Following a stay at the Philipps-University in Marburg, Dr. Mahrwald qualified as a lecturer at the Humboldt University Berlin, where he is now full professor.