Molecular Neurosurgery with Targeted Toxins
| Autor: | Ronald G. Wiley, Douglas A. Lappi |
|---|---|
| EAN: | 9781592598960 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 10.10.2007 |
| Kategorie: | |
| Schlagworte: | Alzheimer Alzheimer´s disease CNS aging alzheimer's disease anatomy brain cognition forebrain neurons neurosurgery physiology protein research surgery |
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Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.
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