Novel Hydroxamic Acid-Derived Ligands for Vanadium Catalysed Asymmetric Epoxidations

Research Paper (postgraduate) from the year 2007 in the subject Chemistry - Organic Chemistry, grade: 1,0, University of Glasgow (Chemistry), language: English, abstract: During this project, we reached the aim of establishing synthetic routes to new hydroxamic acid derivatives, which were used as ligands for asymmetric epoxidation of allylic alcohols in water. Three new ligands, (S, R)-3, (S, S)-3 and 14 were successfully synthesized and subsequently tested on standard substrates. To accomplish the ligand synthesis, we used known procedures as well as new ones, for example the coupling of in situ-protected hydroxylamine 5a and activated mixed anhydride 13. As yields were not always satisfying (see Experimental), optimization of several steps could be a general aim for future work, especially considering the synthesis up-scaling of promising ligand 14.

Der Autor studierte Chemie an der TU Kaiserslautern und promovierte 2012 in Organischer Chemie. Er war Stipendiat der Stiftung der Deutschen Wirtschaft und absolvierte Forschungsaufenthalte an der University of Glasgow (UK) und bei mehreren Chemieunternehmen. Dominik M. Ohlmann ist bei BASF tätig und hatte mehrere Stationen in der zentralen Forschung und im Marketing.