Optimized Response-Adaptive Clinical Trials
| Autor: | Thomas Ondra |
|---|---|
| EAN: | 9783658083441 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 03.12.2014 |
| Untertitel: | Sequential Treatment Allocation Based on Markov Decision Problems |
| Kategorie: | |
| Schlagworte: | Allocation Sequence Backward Induction Clinical Trial Designs Policy Iteration Value Iteration |
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Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.
Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.
Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.
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