Oral Bioavailability Assessment
Autor: | El-Kattan, Ayman F |
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EAN: | 9781118916698 |
Sachgruppe: | Chemie |
Sprache: | Englisch |
Seitenzahl: | 448 |
Produktart: | Gebunden |
Herausgeber: | Lee, Mike S |
Veröffentlichungsdatum: | 06.06.2017 |
Untertitel: | Basics and Strategies for Drug Discovery and Development |
Schlagworte: | Medical / Nursing |
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Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development. * Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability * Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development * Explains how preclinical animal models - used in preclinical testing - and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development * Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) * Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development