PEGylated Protein Drugs: Basic Science and Clinical Applications
| Autor: | Francesco M. Veronese |
|---|---|
| EAN: | 9783764386795 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 30.12.2009 |
| Kategorie: | |
| Schlagworte: | Nucleotide PEG preparation PEGylation technique Pegfilgrastim Protein conjugation cancer cancer therapy interferon necrosis pharmaceutical preparation protein proteins research toxicity |
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PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
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