Pathobiology of Cell Membranes

Pathobiology of Cell Membranes, Volume II, is the second in a multivolume treatise on pathobiological aspects of cell membranes that aims to give the reader an overview of developments concerning the role of altered cell membranes in various pathological processes. This volume includes not only information on pathobiological aspects of cell membranes as studied at the molecular and subcellular level but also important new advances in the role of membranes in human diseases such as multiple sclerosis, shock lung, muscle dystrophies, and hematological disorders. The book begins by discussing a very important and yet poorly known aspect of cellular metabolism; namely, the compartmentalization of intracellular cations such as sodium, calcium, and magnesium. This is followed by separate chapters on fundamentals of membrane conformational changes in the erythrocyte model; the structure and function of peroxisomes and their role in disease processes; the use of invertebrate models for studies of pathological reactions; and reactions of lysosomes to cellular injury. Subsequent chapters deal with the pathology of skeletal muscle membranes; the shock lung syndrome; cellular mechanisms involved in jaundice and cholestasis; and pathology of the endothelium.