Phosphoinositide 3-kinase in Health and Disease
Autor: | Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt |
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EAN: | 9783642136634 |
eBook Format: | |
Sprache: | Englisch |
Produktart: | eBook |
Veröffentlichungsdatum: | 17.10.2010 |
Untertitel: | Volume 1 |
Kategorie: | |
Schlagworte: | PDK1 PI3K TOR kinase domain inhibitor haematological malignancies malignant glioma oncogenesis oncoprotein |
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From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here