Photoaffinity Labeling for Structural Probing Within Protein
| Autor: | Yasumaru Hatanaka, Makoto Hashimoto |
|---|---|
| EAN: | 9784431565697 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 25.09.2017 |
| Kategorie: | |
| Schlagworte: | Affinity-based profiling Binding site Bioactive molecule Carbene Chemical biology Cross-linking Diazirine Drug discovery Ligand receptor Membrane protein Molecular recognition Multifunctional probe Photoactivatable probe Protein analysis |
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This book covers the most up-to-date photoaffinity labeling method to tackle the key loop module involved in the binding process of a bioactive small molecule to its host protein. The book introduces rational points for preparing powerful photoaffinity probes, keys for the efficient analysis of labeled products, and recent successful applications for protein probing. Regarding drug design, the unique topics of the book are the special consideration of the crosslinking potential of recent probes and their application of important receptor proteins . This book presents emerging technologies of photoaffinity labeling to readers who are working in the fields of proteomics, molecular recognition, and drug discovery and development.
?Yasumaru Hatanaka, PhD
Executive Vice President, University of Toyama
?Yasumaru Hatanaka, PhD
Executive Vice President, University of Toyama
Toyama, Japan
Makoto Hashimoto, PhD
Graduate School of Agriculture, Hokkaido University
Sapporo, Japan
Graduate School of Agriculture, Hokkaido University
Sapporo, Japan
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