| EAN: | 9780128191323 |
|---|---|
| Sachgruppe: | Biologie |
| Sprache: | Englisch |
| Seitenzahl: | 450 |
| Produktart: | Kartoniert / Broschiert |
| Herausgeber: | Pey, Angel L |
| Veröffentlichungsdatum: | 19.02.2020 |
| Untertitel: | Mechanisms and Novel Therapies |
| Schlagworte: | Science |
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Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders.