Protein Homology Detection Through Alignment of Markov Random Fields
| Autor: | Ma, Jianzhu Wang, Sheng Xu, Jinbo |
|---|---|
| EAN: | 9783319149134 |
| Sachgruppe: | Biologie Informatik, EDV |
| Sprache: | Englisch |
| Seitenzahl: | 60 |
| Produktart: | Kartoniert / Broschiert |
| Veröffentlichungsdatum: | 03.03.2015 |
| Untertitel: | Using MRFalign |
| Schlagworte: | Bioinformatik Biostatistik Datenverarbeitung / Anwendungen / Mathematik, Statistik Informatik / Bioinformatik Statistik / Biostatistik |
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This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method.
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