Protein-Protein Interactions in Drug Discovery
| Autor: | Alexander Dömling, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers |
|---|---|
| EAN: | 9783527648238 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 24.01.2013 |
| Kategorie: | |
| Schlagworte: | autoimmune disorders cancer drug discovery drug targets infectious diseases medicinal chemist pharmaceutical companies pr protein-protein protein-protein interactions protein-protein interactions in drug discovery small molecule modulators |
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Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.
The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach.
The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach.
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