Protein Tyrosine Phosphatases in Cancer

This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts.

Dr. Neel earned his PhD in Viral Oncology from The Rockefeller University and his MD degree from Cornell University Medical School. After completing residency and post-doctoral training at Harvard institutions, he was appointed Assistant Professor of Medicine at Harvard Medical School (HMS), and began his own independent research laboratory in the Molecular Medicine Unit at Beth Israel Hospital in Boston, now known as Beth Israel Deaconess Medical Center (BIDMC). He also served as the Director of the Cancer Biology Program and as Deputy Director for Basic Research, Hematology Division at BIDMC. Currently, Dr. Neel is Director of the Laura and Isaac Perlmutter Cancer Center at New York University Langone Medical Center, as well as a Professor in the Department of Medicine at NYU.