Quadruplex Nucleic Acids As Targets For Medicinal Chemistry
| Autor: | Stephen Neidle |
|---|---|
| EAN: | 9780128210185 |
| eBook Format: | ePUB/PDF |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 26.08.2020 |
| Kategorie: | |
| Schlagworte: | AGCGA-quadruplex Alternative lengthening of telomere (ALT) Antibody Anticancer agent Antigenic stimulation Antiviral therapy Azide-alkyne cycloaddition Binding mode Biological activity Biophysics Cancer Cancer therapy Cation Chemotype di |
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The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Annual Reports in Medicinal Chemistry series
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