Redox Regulation and Therapeutic Approaches in Cancer

This book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.

Dr Mohinder Pal Bansal did MSc (Honours) in Biophysics in 1972 and PhD in 1980 on carcinogenesis from Department of Biophysics, Panjab University, Chandigarh (India). He worked as a faculty member since 1978 in the above department and superannuated in 2008 as professor. Main subject taught were Mammalian Physiology, Basic Molecular Biology, and Gene & Protein Engineering. After superannuation, he worked as emeritus fellow/scientist sponsored by UGC and ICMR for five years. During sabbaticals he has also worked as Research Associate and Visiting Faculty at the prestigious institution Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA. During this period, he has worked on the isolation and characterization of selenoproteins (having anticancer activity) and published work in reputed scientific journals. His core area of the research involved molecular pathophysiology under the influence of experimental oxidative stress and its modulation in spermatogenesis, atherosclerosis and carcinogenesis. Regulation of gene expression related to the endogenous antioxidative enzymes, transcription factors and their upstream activators (MAP kinases) were studied at transcriptional and translational level using RT-PCR and immunohistochemistry/ELISA etc.

He was listed as reviewer for various international research journals. Out of his total 114 research publications, many are in the peer-reviewed national and international journals. He has authored two books, one as single author and another shared.