Regulation of Membrane Na+-K+ ATPase
Autor: | Sajal Chakraborti, Naranjan S. Dhalla |
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EAN: | 9783319247502 |
eBook Format: | |
Sprache: | Englisch |
Produktart: | eBook |
Veröffentlichungsdatum: | 16.12.2015 |
Kategorie: | |
Schlagworte: | Cardiac Na+-K+ ATPase Membrane Na+-K+ ATPase Na+-K+ pump Na+-coupled cotransport Na+/K+-ATPase inhibitors |
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Na+-K+ ATPase or Na-pump ATPase, a member of 'P'-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it's a- and ß- subunits. At present four different a- (a-1,a-2,a-3 and a-4) and three ß- (ß-1, ß-2, and ß-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of a- and ß- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra
ne domain adjacent to the isoform(s) of a-ß subunits of Na+-K+ ATPase. Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled 'Regulation of Membrane Na+-K+ ATPase' for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease.