SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

Includes updated profiles of SCF and APC cellular functions and their characterized ubiquitin substratesIntroduces the emergent SCF family members in the human genome and summarizes phenotypes in which the adapter proteins of SCF and APC are manipulated to reflect the pathogenesis of human cancerDiscusses how SCF and APC may represent promising therapeutic targets to treat various types of cancersIncludes supplementary material: sn.pub/extras

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SCF and APC E3 Ubiquitin Ligases in Tumorigenesis Hiroyuki Inuzuka, Wenyi Wei

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