Synthesis of Nanoparticles Using Green Chemistry

Document from the year 2017 in the subject Chemistry - Bio-chemistry, Mansoura University, language: English, abstract: Forty-two medicinal plants were collected depending on their availability on Egypt. These plant were extracted and screened for their activity towards green synthesis of AgNPs. A new modified method was used in order to screen large number of extracts in short time (high throughput screening). In this method, the synthesized nanoparticles were evaluated in using 96-well plate which is transparent to facilitate the color monitoring and easy to be read spectrophotometrically using microplate reader. The green synthesis activity by the different plant extracts was monitored and evaluated by color change and UV-Vis absorption at time intervals. Out of these 42 plants, only 3 plants viz.,Pyllanthusemblicafruits, Psidium guajava leaves and Lawsoniainermisleaves, showed high AgNPs synthetic activity. The most active plant extracts were further partitioned with ethyl acetate. The results showed that the EtOAc fraction of the three active plants showed superior AgNPs green synthesis over their remaining aqueous. Thus, chromatographic columns were used to isolate the active compounds from the EtOAc fraction of each plant. Metal nanoparticles synthesis is a leading topic of research in modern material science owing to their distinctive potential applications in the field of electronic, optoelectronic, information storage and Health care. Among the all noble metal nanoparticles, silver nanoparticles are one the main products in the field of nanotechnology which has acquired limitless attention due to their unique properties such as chemical stability, good conductivity, catalytic and most important antibacterial, antiviral and antifungal activities. Nevertheless, there is still need for economic commercially viable as well as environmentally clean synthesis route to synthesize the silver nanoparticles.

Professor Farid Badria, (currently an Emeritus Professor in Pharmacognosy De-partment), Ph.D. in Microbial Transformation from the University of Mississippi, USA, and 2 Masters of Science in Pharmacognosy and Cell Biology from Egypt and USA TWAS-ARO- TWAS-ARO, in 'Public Understanding and Popularization of Sci-ence (2013), World Intellectual Property Organization (WIPO) Gold Medal as The Best Inventor in Egypt (2011), Recognition Outstanding Award in Medicine (Egypt, 2001), Outstanding Arab Scholar, Kuwait (2000); Khawrazmi Award, Iran (2000), are just to mention some of the awards he received. Prof. Badria has submitted 43 patents, of which 16 had been granted certificates with intellectual protection for 20 years. With over 200 publica-tions, 8 books, and many review articles, He continues to lead research projects on: developing new therapy for liver disorders, arthritis, skin disor-ders, and biomarkers for cancer. Research Interests: Applications of Artificial Intelligence in Medical and Pharmaceutical Sciences -Diagnosis of Cancers (Ovarian and Liver) -Diagnosis of Pathological Disorders of Retina. -Decision Making of Viral infection of liver. -Prediction of Health Hazards of Obesity. -Predication of Developing Liver Cancer -Optimization of Extraction Methods of Medicinal plants. NEW THERAPEUTICS AGENTS AS ENZYMES MODULATORS -Inhibitors for Aldose reductase for treatment of Cataract -Inhibitors for Amylase and Glucosidase for treatment of Obesity and Diabetes. -Inhibitors for Proline hydroxylase for treatment of Liver Fibrosis. -Inhibitors for Tyrosinase for treatment of Hyperpigmentation. -Inhibitors for Hyaluronidase for treatment of skin aging -Inhibitors for Topoisomerase for treatment of cancer -Inhibitors for Leukotriene Hydrolase for treatment of Inflammatory Disorders (Hepatitis, IBS, Bronchial Asthma) Developing New Therapy for Liver Disorders -Hepatoselective Fibrosuppressive Agents from Natural Origin. -Early Diagnosis and Intervention of Progress of Liver Cancer -Mechanism of Natural Products on Hepatic Stellate Cells, fatty liver, and HCC. -Natural Endogenous Interferon Stimulant from Natural Products -Schistomicidal Agents Developing New Therapy for Skin Disorders: -Phytotherapy for Alopecia Aerata -New Phytotherapy for Hirsutism and Hyperpigmentation disorders -New Therapy for Amyloidosis Biomarkers: A New Marker for Hepatocellular Carcinoma, nephropathy, and liver fibrosis -