Telomeres and Telomerase in Aging, Disease, and Cancer
| Autor: | K. Lenhard Rudolph |
|---|---|
| EAN: | 9783540737094 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 07.11.2007 |
| Untertitel: | Molecular Mechanisms of Adult Stem Cell Ageing |
| Kategorie: | |
| Schlagworte: | Ageing DNA Telomere aging apoptosis cancer cell cell lines development influence molecular mechanisms proliferation senescence stem cell stem cells |
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Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.
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