The Serotonin Receptors
| Autor: | Kim A. Neve, Bryan L. Roth |
|---|---|
| EAN: | 9781597450805 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 17.08.2008 |
| Untertitel: | From Molecular Pharmacology to Human Therapeutics |
| Kategorie: | |
| Schlagworte: | Nervous System biology brain dementia depression drug drug discovery genome molecular biology neuroanatomy neurotransmitter pharmacology physiology schizophrenia serotonin |
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A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
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