The new heteroaryl compounds having 5-HT1A / 5-HT2A affinity
| Autor: | Dhanawat, Minakshi Sharma, Gaurav Kumar Shrivastava, Sushant Kumar |
|---|---|
| EAN: | 9783659694882 |
| Sachgruppe: | Medizin |
| Sprache: | Englisch |
| Seitenzahl: | 140 |
| Produktart: | Kartoniert / Broschiert |
| Veröffentlichungsdatum: | 14.04.2015 |
| Untertitel: | Design,synthesis & evaluation of some new heteroaryl compounds having 5-HT1A/5-HT2A affinity and anticonvulsant activity |
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The ultimate goal of the experiments conducted in the realm of this work was to design, synthesize, characterize some novel heterocyclic compounds comprising of 4-arylpiperazine/ aniline moiety linked to a terminal cyclic amide through a spacer followed by their biological evaluation and molecular modeling studies as anti-convulsants and evaluation of their interactions with 5-HT1A and 5-HT2A receptor subtypes as agonist/antagonist through validated in vivo behavioral models.
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