Total Synthesis of (±)-Maoecrystal V
| Autor: | Jianxian Gong |
|---|---|
| EAN: | 9783642543043 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 08.07.2014 |
| Kategorie: | |
| Schlagworte: | Intramolecular Diels-Alder Reaction Maoecrystal V Natural Product Pinhey Arylation Stereoselective Tetrahydrofuran Oxa-Bridge Skeleton Total Synthesis Wessely Oxidative Dearomatization |
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In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.
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