Tumor-Induced Immune Suppression
| Autor: | Dmitry I. Gabrilovich, Arthur A. Hurwitz |
|---|---|
| EAN: | 9780387691183 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 01.01.2008 |
| Untertitel: | Mechanisms and Therapeutic Reversal |
| Kategorie: | |
| Schlagworte: | Antigen B7-H1/PD-1 Dendritic Cells Immune Suppressive Mechanisms Macrophages T Cell Tumor Development apoptosis cancer immunobiology inhibitory pathway molecular mechanisms regulation |
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This monograph, for the first time, presents a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It discusses a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance. There is now a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in a more or less cohesive structure and how they can help to improve immune response to tumors.
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