Untranslated Gene Regions and Other Non-coding Elements
Autor: | Barrett, Lucy W. Fletcher, Sue Wilton, Steve D. |
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EAN: | 9783034806787 |
Sachgruppe: | Biologie |
Sprache: | Englisch |
Seitenzahl: | 64 |
Produktart: | Kartoniert / Broschiert |
Veröffentlichungsdatum: | 09.07.2013 |
Untertitel: | Regulation of Eukaryotic Gene Expression |
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There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as ¿junk DNA¿, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5¿ and 3¿ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.¿