Untranslated Gene Regions and Other Non-coding Elements
Autor: | Lucy W. Barrett, Sue Fletcher, Steve D. Wilton |
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EAN: | 9783034806794 |
eBook Format: | |
Sprache: | Englisch |
Produktart: | eBook |
Veröffentlichungsdatum: | 26.06.2013 |
Untertitel: | Regulation of Eukaryotic Gene Expression |
Kategorie: | |
Schlagworte: | DNA regulation Gene expression Introns Junk DNA Non-coding RNA Promotors |
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There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as 'junk DNA', it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.?