Coarse-Grained Modelling of DNA and DNA Self-Assembly
Autor: | Ouldridge, Thomas E. |
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EAN: | 9783642305160 |
Sachgruppe: | Biologie |
Sprache: | Englisch |
Seitenzahl: | 188 |
Produktart: | Gebunden |
Veröffentlichungsdatum: | 07.07.2012 |
Schlagworte: | Biophysik Materie Nanotechnologie Physik / Biophysik Polymere - Polymerisation Statistik Technologie / Nanotechnologie |
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This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker ¿ the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.