Coarse-Grained Modelling of DNA and DNA Self-Assembly
| Autor: | Thomas E. Ouldridge |
|---|---|
| EAN: | 9783642305177 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 09.07.2012 |
| Kategorie: | |
| Schlagworte: | Biological Motors Coarse Grained Molecular Simulation DNA Nanotechnology DNA Tweezers DNA Walker Molecular Self-Assembly Monte Carlo Algorithms |
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This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
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