RNA Therapeutics
Autor: | Paloma H. Giangrande, Vittorio de Franciscis, John J. Rossi |
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EAN: | 9780128217399 |
eBook Format: | ePUB/PDF |
Sprache: | Englisch |
Produktart: | eBook |
Veröffentlichungsdatum: | 10.04.2022 |
Untertitel: | The Evolving Landscape of RNA Therapeutics |
Kategorie: | |
Schlagworte: | : Transcriptional gene silencing Antisense Aptamers CRISPR/Cas9 R RNA RNA Therapeutics TLR agonists/antagonists Targeting DNA Targeting RNA Transcriptional gene activation functional protein ligands miRNAs siRNAs splice switching oligos |
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RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development. - Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies - Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics - Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects