| EAN: | 9783642402517 |
|---|---|
| Sachgruppe: | Medizin |
| Sprache: | Englisch |
| Seitenzahl: | 140 |
| Produktart: | Gebunden |
| Herausgeber: | Boehm, Thomas Takahama, Yousuke |
| Veröffentlichungsdatum: | 19.11.2013 |
| Schlagworte: | Erblehre Genetik Immunsystem - Immunologie - Immun - Autoimmunität |
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The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
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