Thymic Development and Selection of T Lymphocytes
| Autor: | Thomas Boehm, Yousuke Takahama |
|---|---|
| EAN: | 9783642402524 |
| eBook Format: | |
| Sprache: | Englisch |
| Produktart: | eBook |
| Veröffentlichungsdatum: | 06.11.2013 |
| Kategorie: | |
| Schlagworte: | Adaptive immunity Autoimmunity Cellular immunity Immunodeficiency Thymus function |
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The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
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